MPP8-H3K9 Interactions

Description

M-phase phosphoprotein 8 (MPP8) is gene regulation protein that recognises methylated lysine-9 on histone H3. Lysine is positively charged while DNA is negatively charged so they interact favourably, acetylation masks this charge to make the wound DNA more available while methylation allows other molecules to discern it. Molecules with the ability to recognise this property are called readers and can lead to further mediation. In this case the binding causes changes in the expression of the E-cadehrin gene which, in turn, can regulate tumour progression. This shows an overview of the interactions between the MPP8 chromodomain and histone H3, specifically how it binds to H3K9me3. References: https://doi.org/10.1016/j.jmb.2011.03.018 https://doi.org/10.1038/emboj.2010.239